Facile synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1, 2, 4-oxadiazoles from acylthiourea

G Chennakrishnareddy, H Debasis, R Jayan…

Index: Chennakrishnareddy, Gundala; Debasis, Hazra; Jayan, Rapai; Manjunatha, Sulur G. Tetrahedron Letters, 2011 , vol. 52, # 46 p. 6170 - 6173

Full Text: HTML

Citation Number: 8

Abstract

Facile and selective synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1, 2, 4-oxadiazoles starting from N-acylthioureas has been demonstrated. The regio-selectivity is achieved by simply selecting an appropriate base used for the generation of hydroxyl amine from the corresponding hydrochloride salt. This method also avoids the use of toxic cyanogen bromide. The structure of the synthesized oxadiazoles has been resolved by tandem mass ...

Related Articles:

… One??Pot Synthesis of Alkyl 2??(Dialkylamino)??4??phenylthiazole??5??carboxylates and Single??Crystal X??Ray Structure of Methyl 2??(Diisopropylamino)??4??phenylthiazole …

[Souldozi, Ali; Ramazani, Ali; Dadrass, Ali Reza; Slepokura, Katarzyna; Lis, Tadeusz Helvetica Chimica Acta, 2012 , vol. 95, # 2 p. 339 - 348]

Vitamin D deficiency

[Chan, Chung Woo; Ng, Chun Ming Dominic; Ho, Joyce; Tin, Kam Chung Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997 , vol. 36, # 3 p. 216 - 219]

Reactions of carbonyl isothiocyanates with cyclic enamines

[Uher, Michal; Foltin, Jozef; Floch, Lubomir Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 11 p. 2696 - 2702]

Reactions of carbonyl isothiocyanates with cyclic enamines

[Uher, Michal; Foltin, Jozef; Floch, Lubomir Collection of Czechoslovak Chemical Communications, 1981 , vol. 46, # 11 p. 2696 - 2702]

More Articles...