Facile total synthesis of xanthotoxol

…, BL Zhang, SY Zhou, XL Sun, SY Zhang

Index: He, Wei; Zhang, Bang-Le; Zhou, Si-Yuan; Sun, Xiao-Li; Zhang, Sheng-Yong Synthetic Communications, 2007 , vol. 37, # 3 p. 361 - 367

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Citation Number: 5

Abstract

Abstract Xanthotoxol, a biologically active linear furocoumarin, has been efficiently synthesized from 7??hydroxycoumarin in six steps. The key steps included two efficient rearrangements—Fries rearrangement and Claisen rearrangement—and a Baeyer–Villiger oxidation process. The overall yield of xanthotoxol was 29%. This approach also provided a new strategy to furnish easily furocoumarins with a hydroxyl group in the framework.

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