Effects of diarylpentanoid analogues of curcumin on chemiluminescence and chemotactic activities of phagocytes

I Jantan, SNA Bukhari, NH Lajis, F Abas…

Index: Jantan, Ibrahim; Bukhari, Syed Nasir Abbas; Lajis, Nordin Haji; Abas, Faridah; Wai, Lam Kok; Jasamai, Malina Journal of Pharmacy and Pharmacology, 2012 , vol. 64, # 3 p. 404 - 412

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Citation Number: 15

Abstract

Objectives A series of 43 curcumin diarylpentanoid analogues were synthesized and evaluated for their inhibitory effects on the chemiluminescence and chemotactic activity of phagocytes in vitro. Methods The effects of the compounds on the respiratory burst of human whole blood and isolated human polymorphonuclear leukocytes (PMNs) were evaluated using a luminol-based chemiluminescence assay and their effect on chemotactic ...