Chiral Primary Amine Catalyzed Asymmetric Direct Cross??Aldol Reaction of Acetaldehyde

…, L Zhang, J Li, S Luo, JP Cheng

Index: Hu, Shenshen; Zhang, Long; Li, Jiuyuan; Luo, Sanzhong; Cheng, Jin-Pei European Journal of Organic Chemistry, 2011 , # 18 p. 3347 - 3352

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Citation Number: 2

Abstract

Abstract The first primary aminocatalytic direct cross-aldol reaction of acetaldehyde is presented. Among the various vicinal diamines screened, the L-tert-leucine derivative 1c in conjunction with (H 4 SiW 12 O 40) 0.25 was identified as the optimal catalyst; good catalytic activity (up to 99% yield in 4 h), and high enantioselectivities (up to 92% ee) were achieved for a range of donors, including aromatic aldehydes and isatin derivatives. Aqueous ...