Mammalian antifertility agents. IV. Basic 3, 4-dihydronaphthalenes and 1, 2, 3, 4-tetrahydro-1-naphthols

D Lednicer, SC Lyster, GW Duncan

Index: Lednicer,D. et al. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 78 - 84

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Citation Number: 95

Abstract

CH 0 m'H-'28 opened with succininiide to afford 21. Basic hydrolysis of this last product led cleanly to 28. To assess the properties of the phenolic amine, the starting tetralone 17 was demethylated by means of aluminum chloride to give 22. Reaction of the phenolic ketone (as its tetrahydropyranyl ether) with the appropriate Grignard reagent followed by mild hydrolysis led to the aminophenol 27 (Tables I11 and IV).