Antagonists of the human A 2A receptor. Part 5: Highly bio-available pyrimidine-4-carboxamides

…, SJ Bamford, S Gaur, AM Jordan, J Lerpiniere…

Index: Gillespie, Roger J.; Bamford, Samantha J.; Gaur, Suneel; Jordan, Allan M.; Lerpiniere, Joanne; Mansell, Howard L.; Stratton, Gemma C. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 10 p. 2664 - 2667

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Citation Number: 20

Abstract

A novel series of antagonists of the human A2A receptor have been identified and have been shown to display good potency and high degrees of selectivity over other receptor sub- types. Displaying in vivo potency in commonly used disease models and high oral bio- availability, this class of compounds may serve as clinically useful treatments for the relief of the symptoms associated with Parkinson's disease.