Cell Stem Cell 2017-04-06

lncRNA-Encoded Polypeptide SPAR(s) with mTORC1 to Regulate Skeletal Muscle Regeneration

Shahragim Tajbakhsh

Index: 10.1016/j.stem.2017.03.016

Full Text: HTML

Abstract

Although prematurely baptized as non-coding, some lncRNAs encode polypeptides with regulatory functions that are implicated in various biological processes. Matsumoto et al. (2017) recently report in Nature that LINC00961 generates SPAR polypeptide that acts via the lysosome to suppress amino-acid-mediated mTORC1 activity, thereby modulating skeletal muscle regenerative response following injury.

Latest Articles:

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

2017-07-13

[10.1016/j.stem.2017.06.004]

Lineage Tracing: Papers and Progress

2017-07-06

[10.1016/j.stem.2017.06.015]

Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity

2017-07-06

[10.1016/j.stem.2017.06.014]

Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success

2017-07-06

[10.1016/j.stem.2017.06.011]

Making HSCs on Demand: Looking Ahead

2017-07-06

[10.1016/j.stem.2017.06.010]

More Articles...