Cell Stem Cell 2017-04-06

Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells

Christopher DeBoever, He Li, David Jakubosky, Paola Benaglio, Joaquin Reyna, Katrina M. Olson, Hui Huang, William Biggs, Efren Sandoval, Matteo D’Antonio, Kristen Jepsen, Hiroko Matsui, Angelo Arias, Bing Ren, Naoki Nariai, Erin N. Smith, Agnieszka D’Antonio-Chronowska, Emma K. Farley, Kelly A. Frazer

Index: 10.1016/j.stem.2017.03.009

Full Text: HTML

Abstract

Working as part of the NextGen consortium, DeBoever et al. use whole-genome and RNA sequencing to map expression quantitative trait loci in a set of 215 human induced pluripotent stem cell lines. These genotype-expression associations provide a foundation for understanding the genetic regulation of gene expression in pluripotent cells.

Latest Articles:

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

2017-07-13

[10.1016/j.stem.2017.06.004]

Lineage Tracing: Papers and Progress

2017-07-06

[10.1016/j.stem.2017.06.015]

Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity

2017-07-06

[10.1016/j.stem.2017.06.014]

Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success

2017-07-06

[10.1016/j.stem.2017.06.011]

Making HSCs on Demand: Looking Ahead

2017-07-06

[10.1016/j.stem.2017.06.010]

More Articles...