Cell Stem Cell 2017-06-01

The Dynamic Identity of Intestinal Cancer Stem Cells

Piero Dalerba

Index: 10.1016/j.stem.2017.05.018

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Abstract

Elimination of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues. In a recent article in Nature, de Sousa e Melo et al. (2017) reveal that intestinal tumors can contain dynamic pools of functionally distinct CSC populations, which seem to interconvert depending on the host tissue microenvironment.

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