Cell Stem Cell 2017-06-08

Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma

Tobias L. Haas, Maria Rita Sciuto, Lidia Brunetto, Cecilia Valvo, Michele Signore, Micol E. Fiori, Simona di Martino, Stefano Giannetti, Liliana Morgante, Alessandra Boe, Michele Patrizii, Uwe Warnken, Martina Schnölzer, Andrea Ciolfi, Chiara Di Stefano, Mauro Biffoni, Lucia Ricci-Vitiani, Roberto Pallini, Ruggero De Maria

Index: 10.1016/j.stem.2017.04.009

Full Text: HTML

Abstract

Haas et al. identify integrin α7 as a functional marker of glioblastoma stem cells by screening a monoclonal antibody library generated against primary glioblastoma (GBM) cells. Functional experiments in culture and in vivo show that the targeting of integrin α7 has potential as a therapeutic avenue for treating this aggressive disease.

Latest Articles:

ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells

2017-07-13

[10.1016/j.stem.2017.06.004]

Lineage Tracing: Papers and Progress

2017-07-06

[10.1016/j.stem.2017.06.015]

Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity

2017-07-06

[10.1016/j.stem.2017.06.014]

Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success

2017-07-06

[10.1016/j.stem.2017.06.011]

Making HSCs on Demand: Looking Ahead

2017-07-06

[10.1016/j.stem.2017.06.010]

More Articles...