Nature Neuroscience 2017-06-27

A checkpoint to pain

Michael Hirth, Jagadeesh Gandla, Rohini Kuner

Index: 10.1038/nn.4586

Full Text: HTML

Abstract

The checkpoint pathway consisting of programmed death ligand 1 (PD-L1) and its receptor, PD-1, modulates immune function in cancer and infection, but unexpectedly, it also silences pain signals in nerves.

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