Nature Genetics 2017-06-28

Transposase-driven rearrangements in human tumors

Stephen C Mack, Hiromichi Suzuki, Michael D Taylor

Index: 10.1038/ng.3908

Full Text: HTML

Abstract

A new study shows that aberrant DNA transposase activity promotes structural alterations that are clonally selected to drive tumor development. This discovery uncovers novel mechanisms of tumor-suppressor gene inactivation and highlights a new approach to cancer gene identification.

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