Phenylalanine derivatives enhancing intestinal absorption of insulin in mice.

Y Amino, K KAWADA, K TOI, I KUMASHIRO…

Index: Amino; Kawada; Toi; Kumashiro; Fukushima Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4426 - 4434

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Citation Number: 79

Abstract

The adjuvant effect of N-acyl-L-and D-phenylalanine derivatives on intestinal absorption of insulin was investigated in normal mice. The correlation between the chemical structural properties of the N-acyl moiety and the absorption-promoting activity was estimated from the glucose concentrations and the insulin levels in the blood of mice after oral combined administration of insulin and adjuvant. The chemical structural properties of N-acyl- ...

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