Synthesis of novel chromene scaffolds for adenosine receptors

M Costa, F Areias, M Castro, J Brea, MI Loza…

Index: Costa, Marta; Areias, Filipe; Castro, Marian; Brea, Jose; Loza, Maria I.; Proena, Fernanda Organic and Biomolecular Chemistry, 2011 , vol. 9, # 11 p. 4242 - 4249

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Citation Number: 6

Abstract

A one-pot procedure was developed for the synthesis of novel 3-[amino (methoxy) methylene]-2-oxo-3, 4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno [3, 4-c] pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.

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