Synthetic Communications®

Facile and Versatile Room-Temperature Synthesis of N, N-Disubstituted Cyanoacetamides from Malonic Ester Chloride

A Manikowski, Z Kolarska

Index: Manikowski, Andrzej; Kolarska, Zofia Synthetic Communications, 2009 , vol. 39, # 20 p. 3621 - 3638

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Citation Number: 7

Abstract

N,N-Disubstituted cyanoacetamides (Scheme 1) have been recognized as valuable compounds and are widely used in many synthetic operations. Thanks to different features of chemical groups in their molecular backbone, cyanoacetamides can serve as building blocks for preparation of derivatives that are of interest in pharmaceutical, [ 1 1. (a) Manikowski , A. ; Kolarska , Z. ; Jerkovic , J. A process for preparing entacapone. WO Patent Application 2008007093 . Chem. ...

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