Chemistry Letters

Convenient peptide synthesis without protection of C-terminals

T Noguchi, N Tehara, Y Uesugi, S Jung, N Imai

Index: Noguchi, Takuya; Tehara, Naoka; Uesugi, Yuki; Jung, Seunghee; Imai, Nobuyuki Chemistry Letters, 2012 , vol. 41, # 1 p. 42 - 43

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Citation Number: 7

Abstract

Condensation of carboxylic acids 1 and 5 with unprotected α-amino acids 2 via activation by ethyl chloroformate and triethylamine proceeded effectively to afford the corresponding amides in 50–99% yields. Tripeptide 7c was obtained in 42% yield from the dipeptide 6c in a similar manner.

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