Development of bioactive functions in Hydrangeae dulcis folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific …

…, N MURAKAMI, H SHIMODA, J YAMAHARA…

Index: Yoshikawa, Masayuki; Shimada, Hiromi; Yagi, Nobuhiro; Murakami, Nobutoshi; Shimoda, Hiroshi; Yamahara, Johji; Matsuda, Hisashi Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 10 p. 1890 - 1898

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Citation Number: 36

Abstract

Lactonization reaction of 2-carboxystilbene mediated by copper (II) chloride proceeded regiospecifically to give the five-membered lactone, while the bromolactonizations using N- bromosuccinimide and anodic oxidation were found to furnish the six-membered lactone. Using these regiospecific lactonization reactions as a key step, antiallergic and antimicrobial isocoumarins and the benzylidenephthalides thunberginols A and F and their 3'- ...

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