An efficient synthesis of substituted cytosines and purines under focused microwave irradiation

…, YC Cherng, YR Cheng, JP Jang, YL Chao, YJ Cherng

Index: Huang, Ling-Kuen; Cherng, Yen-Chih; Cheng, Yann-Ru; Jang, Jing-Pei; Chao, Yi-Ling; Cherng, Yie-Jia Tetrahedron, 2007 , vol. 63, # 24 p. 5323 - 5327

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Citation Number: 39

Abstract

A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5- bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99% in a short reaction time.