The fungal phytotoxin alternariol 9-methyl ether and some of its synthetic analogues inhibit the photosynthetic electron transport chain

AJ Demuner, LCA Barbosa, ACM Miranda…

Index: Demuner, Antonio Jacinto; Barbosa, Luiz Claudio Almeida; Miranda, Ana Cristina Mendes; Geraldo, Guilherme Carvalho; Da Silva, Cleiton Moreira; Giberti, Samuele; Bertazzini, Michele; Forlani, Giuseppe Journal of Natural Products, 2013 , vol. 76, # 12 p. 2234 - 2245

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Citation Number: 16

Abstract

Alternariol and monomethylalternariol are natural phytotoxins produced by some fungal strains, such as Nimbya and Alternaria. These substances confer virulence to phytopathogens, yet no information is available concerning their mode of action. Here we show that in the micromolar range alternariol 9-methyl ether is able to inhibit the electron transport chain (IC50= 29.1±6.5 μM) in isolated spinach chloroplasts. Since its ...