Scope and mechanism of palladium-catalyzed amination of five-membered heterocyclic halides

MW Hooper, M Utsunomiya…

Index: Hooper, Mark W.; Utsunomiya, Masaru; Hartwig, John F. Journal of Organic Chemistry, 2003 , vol. 68, # 7 p. 2861 - 2873

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Citation Number: 244

Abstract

Detailed studies have been conducted to determine the activity of palladium catalysts for the amination of five-membered heterocyclic halides and to determine the factors that control the scope of this reaction. Palladium-catalyzed aminations of the electron-rich furanyl, thiophenyl, and indolyl halides and of the related 2-halogenated thiazoles, benzimidazole, and benzoxazole have been shown to occur with a subset of amines. Various ...