Tetrahedron

Ring-closing metathesis for the synthesis of heteroaromatics: evaluating routes to pyridines and pyridazines

…, JA Basutto, LP Fishlock, PA Procopiou, CKA Callens

Index: Donohoe, Timothy J.; Bower, John F.; Basutto, Jose A.; Fishlock, Lisa P.; Procopiou, Panayiotis A.; Callens, Cedric K.A. Tetrahedron, 2009 , vol. 65, # 44 p. 8969 - 8980

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Citation Number: 40

Abstract

Ring-closing olefin metathesis (RCM) has been applied to the efficient synthesis of densely and diversely substituted pyridine and pyridazine frameworks. Routes to suitable metathesis precursors have been investigated and the scope of the metathesis step has been probed. The metathesis products function as precursors to the target heteroaromatic structures via elimination of a suitable leaving group, which also facilitates earlier steps by serving as a ...

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