Organic letters

Total synthesis of ageladine A, an angiogenesis inhibitor from the marine sponge Agelas nakamurai

ML Meketa, SM Weinreb

Index: Meketa, Matthew L.; Weinreb, Steven M. Organic Letters, 2006 , vol. 8, # 7 p. 1443 - 1446

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Citation Number: 68

Abstract

In 2003, Fusetani and co-workers described the isolation of ageladine A (1) by bioassay-guided fractionation of the marine sponge Agelas nakamurai Hoshino collected near Kuchinoerabu-jima Island in southern Japan. 1 The structure of this metabolite was established primarily by 2D NMR analysis. Ageladine A shows activity at micromolar levels as an inhibitor of matrixmetalloproteinases (MMPs) which are involved in regulation of angiogenesis. ...