Structurally and Stereochemically Diverse Tetrahydropyran Synthesis through Oxidative C H Bond Activation

L Liu, PE Floreancig

Index: Liu, Lei; Floreancig, Paul E. Angewandte Chemie - International Edition, 2010 , vol. 49, # 17 p. 3069 - 3072

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Citation Number: 58

Abstract

Tetrahydropyrans are core units within a multitude of biologically active natural products,[1] and methods to prepare these structures, which utilize CÀH bond functionalization as a prelude to CÀC bond-formation are desirable. This approach is both step [2] and atom [3] economical, because the substrate preparation and reactive intermediate generation employ unreactive CÀH bonds, rather than conventional leaving groups. We have shown ...

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