NMR study of 5??substituted pyrazolo [3, 4??c] pyridine derivatives

…, N Lougiakis, T Tite, P Marakos, N Pouli…

Index: Tsikouris, Orestis; Bartl, Tomas; Tousek, Jaromir; Lougiakis, Nikolaos; Tite, Tony; Marakos, Panagiotis; Pouli, Nicole; Mikros, Emmanuel; Marek, Radek Magnetic Resonance in Chemistry, 2008 , vol. 46, # 7 p. 643 - 649

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Citation Number: 19

Abstract

Abstract Substituted pyrazolopyridines are potent inhibitors of phosphodiesterases and cyclin-dependent kinases. In this study, NMR was used to investigate the potential N1-H and N2-H tautomerism of 5-substituted pyrazolo [3, 4-c] pyridine derivatives. Six compounds were fully characterized by using 1 H, 13 C, and 15 N chemical shifts and indirect 1 H [BOND] 13 C and 1 H [BOND] 15 N coupling constants. The 1 H NMR spectra were ...