Synthesis and Characterization of Novel Bi-and Tricyclic α-Amino Acids
MR Johnson, JF Gauuan, C Guo, PR Guzzo…
Index: Johnson, Matthew R.; Gauuan, Jolicia F.; Guo, Cheng; Guzzo, Peter R.; Le, Van-Duc; Shenoy, Rajesh A.; Hamby, James; Roark, Howard; Stier, Michael; Mangette, John E. Synthetic Communications, 2011 , vol. 41, # 18 p. 2769 - 2793
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Citation Number: 11
Abstract
Abstract As part of a medicinal chemistry collaboration, a number of novel bi-and tricyclic α- amino acids were prepared through various routes and characterized by 1H nuclear Overhauser effect difference experiments. The syntheses provide a number of routes to access some highly substituted amino acid derivatives that have not been reported previously. It is envisaged that the chemistry described here could be applied to the ...
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