Friedel-Crafts. alpha.-aminoacylation of alkylbenzene with a chiral N-carboxy-. alpha.-amino acid anhydride without loss of chirality

…, T Honnami, A Amano, K Murata, Y Koichi…

Index: Itoh, Osamu; Honnami, Toshiya; Amano, Akira; Murata, Kouichi; Koichi, Youta; Sugita, Toshio Journal of Organic Chemistry, 1992 , vol. 57, # 28 p. 7334 - 7338

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Citation Number: 15

Abstract

A Friedel-Crafts-type a-aminoacylation of alkylbenzene with N-carboxy anhydrides of five La- amino acids was developed. Five new a-aminoalkyl p-methylphenyl ketones and other a- aminoalkyl aryl ketones were obtained and isolated as free bases or hydrochloride salts. The chiralities of the original La-amino acids were retained during this acylation.

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