Journal of Fluorine Chemistry

DAST mediated preparation of β-fluoro-α-aminophosphonates

M Kaźmierczak, H Koroniak

Index: Kazmierczak, Marcin; Koroniak, Henryk Journal of Fluorine Chemistry, 2012 , vol. 139, p. 23 - 27

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Citation Number: 8

Abstract

Herein, we report a new and convenient method for the synthesis of β-fluoro-α- aminophosphonates starting from naturally occurring l-amino acids. A key step in the synthetic protocol involves nucleophilic fluorination of N, N-dibenzylated-β-amino alcohols with diethylaminosulfur trifluoride (DAST).

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