Recommendable Routes to Trifluoromethyl??Substituted Pyridine??and Quinolinecarboxylic Acids

…, M Marull, O Lefebvre, M Schlosser

Index: Cottet, Fabrice; Marull, Marc; Lefebvre, Olivier; Schlosser, Manfred European Journal of Organic Chemistry, 2003 , # 8 p. 1559 - 1568

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Citation Number: 63

Abstract

Abstract As part of a case study, rational strategies for the preparation of all ten 2-, 3-, or 4- pyridinecarboxylic acids and all nine 2-, 3-, 4-, or 8-quinolinecarboxylic acids bearing trifluoromethyl substituents at the 2-, 3-, or 4-position were elaborated. The trifluoromethyl group, if not already present in the precursor, was introduced either by the deoxygenative fluorination of suitable carboxylic acids with sulfur tetrafluoride or by the displacement of ...