Synthesis and biological activities of the respiratory chain inhibitor aurachin D and new ring versus chain analogues

XW Li, J Herrmann, Y Zang, P Grellier…

Index: Li, Xu-Wen; Herrmann, Jennifer; Zang, Yi; Grellier, Philippe; Prado, Soizic; Mueller, Rolf; Nay, Bastien Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1551 - 1558

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Citation Number: 7

Abstract

Abstract Aurachins are myxobacterial 3-farnesyl-4 (1H)-quinolone derived compounds initially described as respiratory chain inhibitors, more specifically as inhibitors of various cytochrome complexes. They are also known as potent antibiotic compounds. We describe herein the first synthesis of aurachin D through a key Conrad–Limpach reaction. The same strategy was used to reach some ring as opposed to chain analogues, allowing for the ...