Anti-influenza Virus Activities of 2-Alkoxyimino-N-(2-isoxazolin-3-ylmethyl) acetamides

…, H Matsumoto, N Hattori, A Takase, T Fujiwara…

Index: Kai, Hiroyuki; Matsumoto, Hiroshi; Hattori, Naohiko; Takase, Akira; Fujiwara, Tamio; Sugimoto, Hirohiko Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 15 p. 1997 - 2000

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Citation Number: 45

Abstract

A series of 2-alkoxyimino-N-(2-isoxazolin-3-ylmethyl) acetamides and related compounds were synthesized and their antiviral activities against human influenza A virus were assessed. Studies of the structure–activity relationships revealed the strongest antiviral activity when position-5 of the isoxazoline ring was substituted with a tert-butyl group. When the alkoxyimino moiety was substituted with a methyl, ethyl, isopropyl or allyl group, good ...