Synthesis of basic substituted pyridines: a new class of antiasthmatic-antiallergic agents

H Anagnostopulos, RR Bartlett, U Elben…

Index: Anagnostopulos, Hiristo; Bartlett, Robert R.; Elben, Ulrich; Stoll, Paul European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 227 - 232

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Citation Number: 11

Abstract

Abstract A series of pyridines were synthesized and evaluated as bronchospasmolytic/anti- allergic agents. Several of these compounds were found to: 1) inhibit the release of histamine; 2) antagonize histamine, bradykinin, LTD 4 and PAF; 3) suppress the IgE- mediated passive cutaneous anaphylaxis (PCA) reaction. The most interesting substance of this series 2, 6-dimethyl-3-nitro-4 [(2-(4-diphenylmethyl-1-piperazinyl) ethyl) amino] ...