The Journal of Organic Chemistry

Synthesis and tubulin binding of 4'-(1-azi-2, 2, 2-trifluoroethyl) oncodazole, a photolabile analog of oncodazole

DL Ladd, PB Harrsch, LI Kruse

Index: Ladd, David L.; Harrsch, Peter B.; Kruse, Lawrence I. Journal of Organic Chemistry, 1988 , vol. 53, # 2 p. 417 - 420

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Citation Number: 12

Abstract

Present address: Department of Medicinal Chemistry, Smith Kline & French Research Ltd., The Frythe, Welwyn, Herts AL6 9AR, England. ruption or hyperstabilization of the mitotic apparatus is presently an area of great interest? We became interested in characterizing the interaction of 1 withtubulin and for this required a photoaffmity analogue of 1. Here we report a synthesis of the 4'-(1-azi-2, 2, 2-trifluoroethyl) analogue (2) of 1.6 The diazirine function ...