Synthesis and reactions of 2, 3-dihydrothiazolo [3, 2-a] pyrimidine derivatives.

T KINOSHITA, Y UESHIMA, K SAITOH…

Index: Kinoshita; Ueshima; Saitoh; et al. Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 1 p. 90 - 96

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Citation Number: 6

Abstract

The reaction of 2-amino-2-thiazoline (1) with acetylene carboxylates (2) afforded 5- substituted 2, 3-dihydro-7H-thiazolo [3, 2-a] pyrimidin-7-ones (3). 7-Bromomethyl-2, 3- dihydro-5H-thiazolo [3, 2-a] pyrimidin-5-one (10) was obtained by the reaction of 1 with γ- bromoacetoacetyl bromide. Treatment of 10 with N-bromosuccinimide provided the 6-bromo compound (12). The 7-bromomethyl compounds (10 and 12) were converted to 7- ...