Macrolide formation by free radical cyclization

NA Porter, VHT Chang

Index: Porter,N.A.; Chang,V.H.T. Journal of the American Chemical Society, 1987 , vol. 109, p. 4976

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Citation Number: 91

Abstract

Conclusions The observed rate constants for the reactions of arylhalocarbenes with alkenes are accelerated by the application of moderate pressures. The magnitude of the activation volumes falls in the range-10 to-18 cm3/mol for rate constants that vary from ca. 5 X lo8 to ca. 1 X lo6 MI sl and are not sensitive to solvent. These results appear to rule out a late, two- bond transition state and a bipolar single-bond transition state, but they are consistent with ...