The synthesis of 4-Substituted Indoles via arenetricarbonylchromium (0) complexes

PJ Beswick, CS Greenwood, TJ Mowlem, G Nechvatal…

Index: Beswick; Greenwood; Mowlem; Nechvatal; Widdowson Tetrahedron, 1988 , vol. 44, # 23 p. 7325 - 7334

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Citation Number: 52

Abstract

Lithiation of tricarbonyl-η6-(1-tri-isopropyisilylindote) chromium (0) and η6-(1-tri- isopropylsilyl-3-methoxymethylindole) tricarbonylchromium (0) followed by an electrophilic quench produced a series of 4-substituted indole complexes. For the 4-acyl,-allyl and- alkenyl analogues, transmetallation of the lithio-species to the corresponding cupro- complexes and reaction with the appropriate halides (in the alkenyl case with palladium ...