Antimycobacterial activities of 5-alkyl (or halo)-3′-substituted pyrimidine nucleoside analogs

…, S Bhavanam, A Agrawal, C Tse, N Desroches…

Index: Srivastav, Naveen C.; Shakya, Neeraj; Bhavanam, Sudha; Agrawal, Amogh; Tse, Chris; Desroches, Nancy; Kunimoto, Dennis Y.; Kumar, Rakesh Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1091 - 1094

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Citation Number: 11

Abstract

Several 5-alkyl (or halo)-3′-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3′-azido-5-ethyl-2′, 3′- dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC50= 1μg/mL), M. tuberculosis (MIC50= 10μg/mL) and M. avium (MIC50= 10μg/mL).