Partial Synthesis of Reichstein's Substance E1

LH Sarett, M Feurer, K Folkers

Index: Sarett et al. Journal of the American Chemical Society, 1951 , vol. 73, p. 1777

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Citation Number: 25

Abstract

The partial synthesis of Reichstein's Substance E, 4-pregnene-ll@, 17a, 20@, 21-tetrol-3- one, has been accomplished via two routes: A, from pregnane-3a, 17a, 20@, 21-tetrol-3-one 20, 21-acetonide by reduction of the 11-ketone with lithium aluminum hydride, partial oxidation by the Oppenauer method and introduction of the 4, 5-double bond; B, by reduction of the% enol ether of cortisone acetate.