2, 4-Dihydro-3H-1, 2, 4-triazol-3-ones as anticonvulsant agents

…, MW Dudley, SM Sorensen, MA Staeger…

Index: Kane; Baron; Dudley; Sorensen; Staeger; Miller Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2772 - 2777

Full Text: HTML

Citation Number: 107

Abstract

A series of 5aryl-2, 4dihydro-3H-1, 2, 4-tri~ l-3-one was evaluated for anticonvulsant activity. In general the members of this series were prepared by the alkaline cyclization of 1-aroyl-4- alkylsemicmbazides. The resulting 2-unsubstituted 3H-1, 2, 4-triazol-3-ones were then alkylated, yielding 2, 4-dialkyl-3H-1, 2, 4-triazol-3-ones, Approximately one-third of the compounds examined exhibited activity against both maximal electroshock-and ...