An Improved Process for the Synthesis of 5-Bromo-3-(1-methylpiperidin-4-yl)-1 H-indole: A Key Intermediate in the Synthesis of Naratriptan Hydrochloride

ND Shashikumar, GN Krishnamurthy…

Index: Organic Process Research and Development, , vol. 14, # 4 p. 918 - 920

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Citation Number: 4

Abstract

... Organic Process Research & Development. ... An improved process has been developed for the synthesis of 5-bromo-3-(1-methylpiperidin-4-yl)-1H-indole, a key intermediate of naratriptan ... A novel one-pot synthetic procedure using triethyl silane was developed for scale-up. ...