Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1 H-pyrrol-1-yl)-1 H-pyrazole-3-carboxamides

R Silvestri, MG Cascio, G La Regina…

Index: Corelli; Massa; Stefancich; Silvestri; Artico; Pantaleoni; Palumbo; Fanini; Giorgi Farmaco, Edizione Scientifica, 1988 , vol. 43, # 3 p. 251 - 265

Full Text: HTML

Citation Number: 57

Abstract

The new 1-phenyl-5-(1 H-pyrrol-1-yl) pyrazole-3-carboxamides were compared with the reference compounds AM251 and SR144528 for cannabinoid hCB1 and hCB2 receptor affinity. Compounds bearing 2, 4-dichlorophenyl or 2, 4-difluorophenyl groups at position 1