Synthesis of (2-(phenylthio) phenyl) acetamidines and related amidoximes as potential antidepressants

K Šindelář, Z Šedivý, M Hrubantová…

Index: Sindelar, Karel; Sedivy, Zdenek; Hrubantova, Marta; Valchar, Martin; Metysova, Jirina; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 2 p. 381 - 388

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Citation Number: 11

Abstract

Abstract Reactions of ethyl (2-(phenylthio) phenyl) acetimidate (X) hydrochloride with ammonia and the corresponding amines resulted in amidines VX. Heating (2-(phenylthio) phenyl) acetonitrile with 2-aminoethylammonium toluene-4-sulfonate led to the 2- imidazoline XI. Reactions of (2-(phenylthio) phenyl) acetonitrile and the lower homologue with hydroxylamine gave the amidoximes XIII and XV; XIII was oxidized to the sulfoxide ...