N-[(Arylmethoxy) phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure

…, RHW Bender, DM Kubrak, D Grimes…

Index: Musser, John H.; Kreft, Anthony F.; Bender, Reinhold H. W.; Kubrak, Dennis M.; Grimes, David; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 240 - 245

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Citation Number: 45

Abstract

Four series of N-[(ary1methoxy) phenyll compounds were prepared as leukotriene D4 (LTD4) antagonists. In the hydroxamic acid series, methyl 3-(2-quinolinylmethoxy) benzeneacetohydroxamate (Wy-48,422, 20) was the most potent inhibitor of LTD4-induced bronchoconstriction with an oral EDa of 7.9 mg/kg. Compound 20 also orally inhibited ovalbumin-induced bronchoconstriction in the guinea pig with an EDa of 3.6 mg/kg. In ...