Heteroaromatic analogs of the. alpha. 2-adrenoreceptor partial agonist clonidine

CB Chapleo, RCM Butler, DC England…

Index: Chapleo, Christopher B.; Butler, Richard C. M.; England, David C.; Myers, Peter L.; Roach, Alan G.; et al. Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1627 - 1630

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Citation Number: 42

Abstract

A 1, 4-dioxane analogue (1) of the ap-adrenoreceptor partial agonist clonidine (2) has previously been shown to possess an interesting but complex pharmacological profile. In this study, from a series of other heterocyclic analogues of clonidine, the 1, 4-oxazines 6 and 12 were found to resemble 1 in that they are partial a2-agonists in the periphery and are excluded from the central nervous system. However, when given directly into the brain, ...