Tetrahedron Letters

A new and efficient method for the facile synthesis of N-acyl sulfonamides under Lewis acid catalysis

CR Reddy, B Mahipal, SR Yaragorla

Index: Raji Reddy, Chada; Mahipal, Bodugam; Yaragorla, Srinivasa Rao Tetrahedron Letters, 2007 , vol. 48, # 42 p. 7528 - 7532

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Citation Number: 28

Abstract

The N-acylation of sulfonamides with carboxylic acid anhydrides in the presence of Lewis acids is described. Several Lewis acids such as BF3· Et2O, ZnCl2, MoCl5, TiCl4, B (C6F5) 3, Sc (OTf) 3 and I2 were found to catalyze the reaction efficiently to furnish the N-acylated products in good yields under solvent-free conditions. The reactions of various sulfonamides were studied with different carboxylic acid anhydrides including the less reactive benzoic ...

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