Tetrahedron

Development of fluorination methods using continuous-flow microreactors

M Baumann, IR Baxendale, LJ Martin, SV Ley

Index: Baumann, Marcus; Baxendale, Ian R.; Martin, Laetitia J.; Ley, Steven V. Tetrahedron, 2009 , vol. 65, # 33 p. 6611 - 6625

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Citation Number: 101

Abstract

The safe and reliable use of various fluorination methods including nucleophilic fluorination (DAST), trifluoromethylation (Ruppert's reagent) and electrophilic fluorination (Selectfluor®) in a continuous-flow microreactor is reported. Special attention was given to the use of in- line scavenging procedures in order to obtain clean products without the need for further purification.