Antihyperglycemic activity of new 1, 2, 4-oxadiazolidine-3, 5-diones

MS Malamas, J Sredy, M McCaleb, I Gunawan…

Index: Malamas, Michael S; Sredy, Janet; McCaleb, Michael; Gunawan, Iwan; Mihan, Brenda; Sullivan, Donald European Journal of Medicinal Chemistry, 2001 , vol. 36, # 1 p. 31 - 42

Full Text: HTML

Citation Number: 57

Abstract

A series of 1, 2, 4-oxadiazolidine-3, 5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse—the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy-and ethoxy- linked oxazole 1, 2, 4-oxadiazolidine-3, 5-diones normalized plasma glucose levels at the 100 mg kg− 1 oral dose in the db/db diabetic mouse model, and several amongst them ...