Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

…, R Corbau, A Marchand, P Chaltin, P Sonveaux…

Index: Draoui, Nihed; Schicke, Olivier; Fernandes, Antony; Drozak, Xavier; Nahra, Fady; Dumont, Amelie; Douxfils, Jonathan; Hermans, Emmanuel; Dogne, Jean-Michel; Corbau, Romu; Marchand, Arnaud; Chaltin, Patrick; Sonveaux, Pierre; Feron, Olivier; Riant, Olivier Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 7107 - 7117

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Citation Number: 22

Abstract

Abstract Under hypoxia, cancer cells consume glucose and release lactate at a high rate. Lactate was recently documented to be recaptured by oxygenated cancer cells to fuel the TCA cycle and thereby to support tumor growth. Monocarboxylate transporters (MCT) are the main lactate carriers and therefore represent potential therapeutic targets to limit cancer progression. In this study, we have developed and implemented a stepwise in vitro ...