An efficient and rapid intramolecular aza-Michael addition of 2′-aminochalcones using ionic liquids as recyclable reaction media

M Chelghoum, M Bahnous, A Bouraiou, S Bouacida…

Index: Chelghoum; Bahnous; Bouraiou; Bouacida; Belfaitah Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4059 - 4061

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Citation Number: 11

Abstract

2,3-Dihydro-2-aryl-4(1H)-quinolinones, which can be considered as aza-analogs of flavanones, demonstrate a wide range of biological activities, for example, as anticancer and immunosuppressive agents. 1 They also serve as valuable precursors of other medicinally important compounds, 2 and 3 which are often not readily accessible by other means. 3 and 4 The formation of 2,3-dihydroquinolin-4(1H)-ones is generally accomplished by acid- or base-catalyzed ...