Synthesis and antihyperglycemic activity of novel 5-(naphthalenylsulfonyl)-2, 4-thiazolidinediones

…, I Jirkovsky, JW Nowicki, ML McCaleb

Index: Zask; Jirkovsky; Nowicki; McCaleb Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1418 - 1423

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Citation Number: 64

Abstract

A series of 5-(naphthalenylsulfony1)-2, 4-thiazolidinediones were synthesized and evaluated for antihyperglycemic activity in an insulin-resistant, genetically diabetic db/db mouse model of non-insulin-dependent diabetes mellitus (NIDDM). The sulfones could be synthesized by a novel, selective C-5 sulfonylation of dilithio-2, 4-thiazolidinedione with appropriate sulfonyl chlorides. Within this series, naphthalene was found to be superior to ...