Synthesis and biological evaluation of 2-alkoxyphenyl-6-(substituted phenyl)-1, 3, 4-thiadiazole-[3, 2-a]-s-triazin-5, 7-diones and 1-(alkyl and substituted phenyl)-3-[5- …

…, R Pignatello, A Panico, G Mazzone, A Corsaro…

Index: Puglisi, Giovanni; Pignatello, Rosario; Panico, Annamaria; Mazzone, Gioacchino; Corsaro, Antonio; et al. European Journal of Medicinal Chemistry, 1989 , vol. 24, p. 277 - 286

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Citation Number: 7

Abstract

Abstract As an extension of a previous work, in which a series of 2-alkoxyphenyl-6-phenyl-1, 3, 4-thiadiazole-[3, 2-a]-s-triazin-5, 7-diones were synthesized and found to possess analgesic activity, a new series of analogues substituted in the 6-phenyl ring has been prepared and tested with the aim of examining the variations induced by phenyl substituents in biological activity, and thus obtaining useful information about the structure—activity ...